1.What's the matter?
2.What's wrong?
3.What's up?
4.What happened?
what's going on?
what's up?
what's wrong?
what's the problem?
What's the matter?
What happened?
不要用how are you
那是打招呼,你好 的意思
How are you ?
What's wrong with you ?
What's up ?
What happened ?